Iodine → HCID 44232945, 화합물

HRID 44633

반응식

HRID 44633 반응식
[CH3:1][NH:2][C:3]([C:5]1[C:9]2[C:10]([CH3:22])([CH3:21])[CH:11](CC)[C:12]3[CH:13]=[N:14][C:15](N)=[N:16][C:17]=3[C:8]=2[N:7]([CH3:23])[N:6]=1)=[O:4].[I-:24].[Cs+].II.N(OCCC(C)C)=O>[Cu]I.C(COC)OC>[CH3:1][NH:2][C:3]([C:5]1[C:9]2[C:10]([CH3:22])([CH3:21])[CH2:11][C:12]3[CH:13]=[N:14][C:15]([I:24])=[N:16][C:17]=3[C:8]=2[N:7]([CH3:23])[N:6]=1)=[O:4]

참가 물질

7

반응물 4

HCID 807IodineHCID 8053Isoamyl NitriteHCID 24601Cesium iodideHCID 68936324Ethyl 8-amino-1,4,4-trimethyl-4,5-dihydro-1h-pyrazolo[4,3-h]quinazoline-3-carboxylic acid methylamide

생성물 1

HCID 44232945HCID 44232945, 화합물

시약·촉매·용매 2

HCID 24350Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI)촉매HCID 80711,2-Dimethoxyethane용매

반응 조건

온도
70 °C

실험 절차

In a round bottom flask maintained under argon atmosphere, ethyl 8-amino-1,4,4-trimethyl-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxylic acid methylamide (13.00 g, 45.400 mmol) was dissolved into anhydrous dimethoxyethane (800 mL); cesium iodide (11.795 g, 45.400 mmol), bisublimated iodine (5.761 g, 22.698 mmol), copper(I) iodide (2.594 g, 13.621 mmol), and iso-amyl nitrite (9.107 mL, 68.100 mmol) were added in that order and the mixture was heated to 70° C. for 22 hours.

후처리

  1. temperatureIn a round bottom flask maintained under argon atmosphere

출처 및 근거

ORD 기록
ord-1712e10069594564bdddcc990bb7193f
출처 데이터셋
uspto-grants-2013_09
특허 번호
US08541429B2

연결된 노트

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