Hydrochloric Acid → (1S)-2-morpholin-4-yl-1-phenylethanamine dihydrochloride

HRID 44638노트

반응식

HRID 44638 반응식
[N:1]1([CH2:7][C@@H:8]([NH:15]C(=O)OC(C)(C)C)[C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1.[ClH:23]>ClCCl.O1CCOCC1.C(OCC)C>[ClH:23].[ClH:23].[N:1]1([CH2:7][C@H:8]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)[NH2:15])[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1

참가 물질

6

반응물 2

HCID 313Hydrochloric AcidHCID 57444157Tert-butyl (1S)-2-morpholin-4-yl-1-phenylethylcarbamate

생성물 1

HCID 57463845(1S)-2-morpholin-4-yl-1-phenylethanamine dihydrochloride수율 90%

시약·촉매·용매 3

HCID 3283Diethyl Ether용매HCID 6344Dichloromethane용매HCID 312751,4-Dioxane용매

실험 절차

A solution of 11.58 g (0.0378 mol) of tert-butyl (1S)-2-morpholin-4-yl-1-phenylethylcarbamate in 100 mL of dichloromethane was treated with 120 mL of HCl 4M in dioxane and stirred for 18 hours. The mixture was diluted with diethylether and the product filtered (9.48 g, 90% yield).

후처리

  1. filtrationthe product filtered (9.48 g, 90% yield)

출처 및 근거

ORD 기록
ord-844ed63e57b24cd986691df297edc7cf
출처 데이터셋
uspto-grants-2013_09
특허 번호
US08541429B2

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