Diethyl Ether → N'-(1-acetylpiperidin-4-ylidene)benzohydrazide

HRID 44646

반응식

HRID 44646 반응식
[C:1]([N:4]1[CH2:9][CH2:8][C:7](=O)[CH2:6][CH2:5]1)(=[O:3])[CH3:2].[C:11]([NH:19][NH2:20])(=[O:18])[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1.C(OCC)C>C(O)C>[C:1]([N:4]1[CH2:9][CH2:8][C:7](=[N:20][NH:19][C:11](=[O:18])[C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[CH2:6][CH2:5]1)(=[O:3])[CH3:2]

참가 물질

5

반응물 3

HCID 3283Diethyl EtherHCID 11955BenzoylhydrazineHCID 122563N-Acetyl-4-piperidone

생성물 1

HCID 57531701N'-(1-acetylpiperidin-4-ylidene)benzohydrazide수율 83%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

20 g (0.142 mol) of 1-acetyl-4-piperidone were dissolved in 400 mL of absolute ethanol and 21.2 g (0.156 mol) of benzoylhydrazine were added. The resulting solution was refluxed for 6 hours under stirring. The solvent was then removed in vacuo and the residue partitioned between dichloromethane and water. The organic layer was dried over sodium sulfate and evaporated to dryness. The residue was triturated with diethylether and 30 g (83% yield) of the title compound were collected by filtration.

후처리

  1. temperatureThe resulting solution was refluxed for 6 hours
  2. customThe solvent was then removed in vacuo
  3. customthe residue partitioned between dichloromethane and water
  4. dry with materialThe organic layer was dried over sodium sulfate
  5. customevaporated to dryness

출처 및 근거

ORD 기록
ord-d168168c723d46c08635a1699a165a5d
출처 데이터셋
uspto-grants-2013_09
특허 번호
US08541429B2

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