Hydrochloric Acid → (4aR,4bS,5S,6aS,6bS,9aR,10aS,10bS)-5-Hydroxy-6b-(2-hydroxy-acetyl)-4a,6a-dimethyl-4b,5,6,6a,6b,7,8,9,9a,10,10a,10b,11,12-tetradecahydro-4aH-8-aza-pentaleno[2,1-a]phenanthren-2-one hydrochloride

HRID 446834노트

반응식

HRID 446834 반응식
[ClH:1].F[C@@:3]12[C@:16]3([CH3:17])[C:11](=[CH:12][C:13](=[O:18])[CH:14]=[CH:15]3)[C@@H:10](F)[CH2:9][C@H:8]1[C@@H:7]1[CH2:20][C@@H:21]3[C@:25]([C:26](=[O:32])[CH2:27][O:28]C(=O)C)([C@@:6]1([CH3:33])[CH2:5][C@@H:4]2[OH:34])[CH2:24][NH:23][CH2:22]3.Cl>CO.O1CCOCC1>[ClH:1].[OH:34][C@@H:4]1[C@H:3]2[C@@H:8]([CH2:9][CH2:10][C:11]3[C@:16]2([CH3:17])[CH:15]=[CH:14][C:13](=[O:18])[CH:12]=3)[C@@H:7]2[CH2:20][C@@H:21]3[C@:25]([C:26](=[O:32])[CH2:27][OH:28])([C@@:6]2([CH3:33])[CH2:5]1)[CH2:24][NH:23][CH2:22]3

참가 물질

5

반응물 2

HCID 313Hydrochloric Acid2회HCID 67353702Acetic acid 2-((4aS,4bR,5S,6aS,6bS,9aR,10aS,10bS,12S)-4b,12-difluoro-5-hydroxy-4a,6a-dimethyl-2-oxo-2,4b,5,6,6a,7,8,9,9a,10,10a,10b,11,12-tetradecahydro-4-aH-8-aza-pentaleno[2,1-a]phenanthren-6b-yl)-2-oxo-ethyl ester hydrochloride

생성물 1

HCID 67351491(4aR,4bS,5S,6aS,6bS,9aR,10aS,10bS)-5-Hydroxy-6b-(2-hydroxy-acetyl)-4a,6a-dimethyl-4b,5,6,6a,6b,7,8,9,9a,10,10a,10b,11,12-tetradecahydro-4aH-8-aza-pentaleno[2,1-a]phenanthren-2-one hydrochloride수율 100%

시약·촉매·용매 2

HCID 887Methanol용매HCID 312751,4-Dioxane용매

실험 절차

In a closed vessel compound 20 (300 mg, 0.600 mmol) is dissolved in MeOH, HCl (0.045 ml, 0.180 mmol) in dioxane is added and the mixture is stirred at room temperature for 10 days, then further HCl (0.045 ml, 0.180 mmol) is added and the reaction mixture is stirred for further 2 days. The reaction mixture is concentrated to dryness affording the title compound (253 mg, 0.600 mmol, 100% yield).

후처리

  1. stirringthe reaction mixture is stirred for further 2 days
  2. concentrationThe reaction mixture is concentrated to dryness

출처 및 근거

ORD 기록
ord-9bf8c21e35034e10a09c8b80b590eccf
출처 데이터셋
uspto-grants-2013_07
특허 번호
US08481517B2

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