Diisopropylethylamine → HCID 67281619, 화합물

HRID 446964

반응식

HRID 446964 반응식
[C:1]([O:5][C:6]([N:8]([CH3:38])[CH:9]([CH3:37])[C:10]([NH:12][CH:13]([CH:31]1[CH2:36][CH2:35][CH2:34][CH2:33][CH2:32]1)[C:14]([N:16]1[CH:23]2[CH:19]([N:20]([S:27]([CH3:30])(=[O:29])=[O:28])[CH2:21][CH:22]2[C:24]([OH:26])=O)[CH2:18][CH2:17]1)=[O:15])=[O:11])=[O:7])([CH3:4])([CH3:3])[CH3:2].CN(C(ON1N=NC2C=CC=NC1=2)=[N+](C)C)C.F[P-](F)(F)(F)(F)F.CCN(C(C)C)C(C)C.[C@H:72]1([NH2:82])[C:81]2[C:76](=[CH:77][CH:78]=[CH:79][CH:80]=2)[CH2:75][CH2:74][CH2:73]1>CN1C(=O)CCC1.CCOC(C)=O>[C:1]([O:5][C:6](=[O:7])[N:8]([CH:9]([C:10](=[O:11])[NH:12][CH:13]([CH:31]1[CH2:32][CH2:33][CH2:34][CH2:35][CH2:36]1)[C:14]([N:16]1[CH2:17][CH2:18][CH:19]2[N:20]([S:27]([CH3:30])(=[O:28])=[O:29])[CH2:21][CH:22]([C:24](=[O:26])[NH:82][CH:72]3[C:81]4[C:76](=[CH:77][CH:78]=[CH:79][CH:80]=4)[CH2:75][CH2:74][CH2:73]3)[CH:23]12)=[O:15])[CH3:37])[CH3:38])([CH3:2])([CH3:4])[CH3:3]

참가 물질

7

반응물 4

HCID 81531DiisopropylethylamineHCID 70580721-Aminotetralin, (R)-HCID 9886157Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1)HCID 672809014-{2-[2-(tert-Butoxycarbonyl-methyl-amino)-propionylamino]-2-cyclohexyl-acetyl}-1-methanesulfonyl-octahydro-pyrrolo[3,2-b]pyrrole-3-carboxylic acid

생성물 1

HCID 67281619HCID 67281619, 화합물

시약·촉매·용매 2

HCID 8857Ethyl Acetate용매HCID 13387N-methyl-2-pyrrolidone용매2회

실험 절차

A solution of crude 21 (106 mg, 0.19 mmol) in NMP (5 mL) was cooled to 0° C. and treated with HATU (73 mg, 0.19 mmol) and DIPEA (0.1 mL, 0.57 mmol). After 10 min, (1R)-1,2,3,4-tetrahydro-naphthalen-1-ylamine (0.05 mL, 0.35 mmol) in NMP (3 mL) was added. The reaction was allowed to warm to ambient temperature. After 16 h, the solution was diluted with EtOAc, washed successively with 1M HCl, brine, dried over anhydrous Na2SO4, filtered and concentrated to afford 22 which was used without further purification. Mass spectrum, m/z [688.5] (M+H)+.

후처리

  1. waitAfter 16 h
  2. washwashed successively with 1M HCl, brine
  3. dry with materialdried over anhydrous Na2SO4
  4. filtrationfiltered
  5. concentrationconcentrated

출처 및 근거

ORD 기록
ord-b3daea1956ff4f86bf1584ccf8fb951d
출처 데이터셋
uspto-grants-2013_07
특허 번호
US08481495B2

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