[1-(4-fluoro-phenyl)-2-methyl-1H-imidazol-4-yl]-methanol → 1-(4-fluoro-phenyl)-2-methyl-1H-imidazole-4-carbaldehyde

HRID 447218

반응식

HRID 447218 반응식
[F:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[CH:12]=[C:11]([CH2:13][OH:14])[N:10]=[C:9]2[CH3:15])=[CH:4][CH:3]=1>C(Cl)Cl.[Mn]>[F:1][C:2]1[CH:3]=[CH:4][C:5]([N:8]2[CH:12]=[C:11]([CH:13]=[O:14])[N:10]=[C:9]2[CH3:15])=[CH:6][CH:7]=1

참가 물질

4

반응물 1

HCID 67303957[1-(4-fluoro-phenyl)-2-methyl-1H-imidazol-4-yl]-methanol

생성물 1

HCID 859979931-(4-fluoro-phenyl)-2-methyl-1H-imidazole-4-carbaldehyde

시약·촉매·용매 2

HCID 23930Manganese촉매HCID 6344Dichloromethane용매

실험 절차

[1-(4-Fluoro-phenyl)-2-methyl-1H-imidazol-4-yl]-methanol (7.16 g, 34.7 mmol) was dissolved in 2.3 L methylene chloride. Mangan (IV) oxid (26.8 g, 278 mmol) was added and the reaction mixture was stirred at room temperature for 3 days. The suspension was filtered through a dicalite speed plus pad and washed with 1 L methylene chloride. The solvents were evaporated and the desired compound was obtained as a white solid (5.87 g, 83%), MS: m/e=205.1 (M+H+).

후처리

  1. filtrationThe suspension was filtered through a dicalite speed plus pad
  2. washwashed with 1 L methylene chloride
  3. customThe solvents were evaporated

출처 및 근거

ORD 기록
ord-4c4455eee7be47ecbbc110bed1916531
출처 데이터셋
uspto-grants-2013_07
특허 번호
US08481548B2

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