Sodium Hydroxide → 4-[(4-amino-2-ethyl-1H-imidazo[4,5-c][1,5]naphthyridin-1-yl)methyl]piperidin-4-ol

HRID 44775

반응식

HRID 44775 반응식
Cl.Cl.[NH2:3][C:4]1[C:13]2[N:14]=[C:15]([CH2:25][CH3:26])[N:16]([CH2:17][C:18]3([OH:24])[CH2:23][CH2:22][NH:21][CH2:20][CH2:19]3)[C:12]=2[C:11]2[N:10]=[CH:9][CH:8]=[CH:7][C:6]=2[N:5]=1.[OH-].[Na+]>>[NH2:3][C:4]1[C:13]2[N:14]=[C:15]([CH2:25][CH3:26])[N:16]([CH2:17][C:18]3([OH:24])[CH2:23][CH2:22][NH:21][CH2:20][CH2:19]3)[C:12]=2[C:11]2[N:10]=[CH:9][CH:8]=[CH:7][C:6]=2[N:5]=1

참가 물질

3

반응물 2

HCID 14798Sodium HydroxideHCID 575155314-[(4-amino-2-ethyl-1H-imidazo[4,5-c][1,5]naphthyridin-1-yl)methyl]piperidin-4-ol dihydrochloride

생성물 1

HCID 575155304-[(4-amino-2-ethyl-1H-imidazo[4,5-c][1,5]naphthyridin-1-yl)methyl]piperidin-4-ol수율 93.3%

실험 절차

A mixture of 4-[(4-amino-2-ethyl-1H-imidazo[4,5-c][1,5]naphthyridin-1-yl)methyl]piperidin-4-ol dihydrochloride (0.80 g) and 1N sodium hydroxide (8 mL) was sonicated for 2 minutes. A solid was isolated by filtration, washed with water, and dried. This procedure was repeated and the material was dried under high vacuum at 120° C. to provide 0.61 g of 4-[(4-amino-2-ethyl-1H-imidazo[4,5-c][1,5]naphthyridin-1-yl)methyl]piperidin-4-ol as a tan powder, mp 232.0-233.0° C. Anal. Calcd for C17H22N6O C, 62.56; H, 6.79; N, 25.75. Found: C, 62.43; H, 7.04; N, 25.78.

후처리

  1. customwas sonicated for 2 minutes
  2. customA solid was isolated by filtration
  3. washwashed with water
  4. customdried
  5. customthe material was dried under high vacuum at 120° C.

출처 및 근거

ORD 기록
ord-016b3782b9094a01bb241c5ad7057869
출처 데이터셋
uspto-grants-2013_09
특허 번호
US08541438B2

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