Iodine chloride → 2-Fluoro-6-iodo-4-methylaniline
반응식
[F:1][C:2]1[CH:8]=[C:7]([CH3:9])[CH:6]=[CH:5][C:3]=1[NH2:4].O.O.O.C([O-])(=O)C.[Na+].[I:18]Cl.C(=O)(O)[O-].[Na+].S([O-])([O-])=O.[Na+].[Na+]>C(O)(=O)C.C(OCC)C>[F:1][C:2]1[CH:8]=[C:7]([CH3:9])[CH:6]=[C:5]([I:18])[C:3]=1[NH2:4]참가 물질
7
실험 절차
A solution of 2-fluoro-4-methylaniline (1.0 g, 8 mmol) (bought from Avocado, Lancaster or Aldrich) in glacial acetic acid (10 ml) was treated with sodium acetate trihydrate (2.2 g, 16 mmol) then iodine monochloride (1.3 g). After 30 min at room temperature aqueous sodium bicarbonate/sodium sulfite and diethyl ether were added, and the organic phase was dried (MgSO4), evaporated and chromatographed on silica eluting with 0 to 30% ethyl acetate in hexane to give the title compound, 370 mg.
후처리
- dry with materialthe organic phase was dried (MgSO4)
- customevaporated
- customchromatographed on silica eluting with 0 to 30% ethyl acetate in hexane
출처 및 근거
- ORD 기록
- ord-1321d7bb5ab84781ba885aa67bff8733
- 출처 데이터셋
- uspto-grants-2013_07
- 특허 번호
- US08481566B2
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