1,4-Dioxane → 1-Bromo-5-chloro-3-fluoro-2-isocyanatobenzene
반응식
[Br:1][C:2]1[CH:8]=[C:7]([Cl:9])[CH:6]=[C:5]([F:10])[C:3]=1[NH2:4].Cl[C:12]([O:15]C(=O)OC(Cl)(Cl)Cl)(Cl)Cl.O1CCOCC1>CO>[Br:1][C:2]1[CH:8]=[C:7]([Cl:9])[CH:6]=[C:5]([F:10])[C:3]=1[N:4]=[C:12]=[O:15]참가 물질
5
반응 조건
- 온도
- 100 °C
실험 절차
2-Bromo-4-chloro-6-fluoroaniline (5 mmol, 1.125 g), bis(trichloromethyl)carbonate (1.7 mmol, 0.50 g) and 1,4-dioxane (10 ml) were mixed together and the mixture was heated to 100° C. for 15 minutes; the mixture was then cooled to room temperature and it was filtered. The filtrate was concentrated to afford a mixture of products (2.2 g) containing the title compound, M++MeO=283 (LC-MS run in methanol).
후처리
- temperaturethe mixture was then cooled to room temperature
- filtrationit was filtered
- concentrationThe filtrate was concentrated
- customto afford
출처 및 근거
- ORD 기록
- ord-88c1552265f04242a7076c8c56a419cf
- 출처 데이터셋
- uspto-grants-2013_07
- 특허 번호
- US08481566B2
반응 노트
불러오는 중…