Dimethylformamide → 1,3-Difluoro-5-methoxy-2-nitrobenzene

HRID 447763노트

반응식

HRID 447763 반응식
[N+:1]([C:4]1[C:9]([F:10])=[CH:8][C:7]([OH:11])=[CH:6][C:5]=1[F:12])([O-:3])=[O:2].[C:13](=O)([O-])[O-].[K+].[K+].IC.CN(C)C=O>O.C(OCC)(=O)C>[N+:1]([C:4]1[C:5]([F:12])=[CH:6][C:7]([O:11][CH3:13])=[CH:8][C:9]=1[F:10])([O-:3])=[O:2]

참가 물질

7

반응물 4

HCID 6228DimethylformamideHCID 6328Methyl iodideHCID 11430Potassium CarbonateHCID 178437653,5-Difluoro-4-nitrophenol

생성물 1

HCID 100127101,3-Difluoro-5-methoxy-2-nitrobenzene

시약·촉매·용매 2

HCID 962Water용매HCID 8857Ethyl Acetate용매

실험 절차

A mixture of 4-nitro-3,5-difluorophenol (D10) (440 mg, 2.5 mmol), potassium carbonate (600 mg, 4.6 mmol), iodomethane (1 ml), and dimethylformamide (5 ml) stirred overnight at room temperature then ethyl acetate and water added and the solution washed with water then dried over MgSO4, filtered and evaporated to yield the title compound, pale brown oil, 370 mg.

후처리

  1. washthe solution washed with water
  2. dry with materialthen dried over MgSO4
  3. filtrationfiltered
  4. customevaporated

출처 및 근거

ORD 기록
ord-374ccba3e5084f579897e548854f4f79
출처 데이터셋
uspto-grants-2013_07
특허 번호
US08481566B2

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