1-Oxo-2,3-Dihydro-1H-Indene-4-Carbonitrile → 1-hydroxy-2,3-dihydro-1H-indene-4-carbonitrile

HRID 447895노트

반응식

HRID 447895 반응식
[O:1]=[C:2]1[C:10]2[CH:9]=[CH:8][CH:7]=[C:6]([C:11]#[N:12])[C:5]=2[CH2:4][CH2:3]1.[BH4-].[Na+]>C(O)C>[OH:1][CH:2]1[C:10]2[CH:9]=[CH:8][CH:7]=[C:6]([C:11]#[N:12])[C:5]=2[CH2:4][CH2:3]1

참가 물질

4

반응물 2

HCID 27515831-Oxo-2,3-Dihydro-1H-Indene-4-CarbonitrileHCID 4311764Sodium borohydride

생성물 1

HCID 145153071-hydroxy-2,3-dihydro-1H-indene-4-carbonitrile수율 80%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

To a stirred suspension of 1-oxo-2,3-dihydro-1H-indene-4-carbonitrile (1.0 equiv, 0.4M) and silica gel (catalytic) in ethanol at 0° C. was added NaBH4 (1/3 equiv). The reaction was allowed to warm up to room temperature and stirred for 2 h. The Solvent was removed under reduced pressure and the product purified by CC in hexane/EtOAc (5:5) to offer 1-hydroxy-2,3-dihydro-1H-indene-4-carbonitrile in 80% yield.

후처리

  1. customThe Solvent was removed under reduced pressure
  2. customthe product purified by CC in hexane/EtOAc (5:5)

출처 및 근거

ORD 기록
ord-2758004e28b5407c87ef25b6e9234d02
출처 데이터셋
uspto-grants-2013_07
특허 번호
US08481573B2

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