Benzoyl Peroxide → 2-(Bromomethyl)-1-chloro-3-methoxybenzene

HRID 447920

반응식

HRID 447920 반응식
[Cl:1][C:2]1[C:3]([CH3:10])=[C:4]([O:8][CH3:9])[CH:5]=[CH:6][CH:7]=1.C(OOC(=O)C1C=CC=CC=1)(=O)C1C=CC=CC=1.[Br:29]N1C(=O)CCC1=O>C(Cl)(Cl)(Cl)Cl>[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([O:8][CH3:9])[C:3]=1[CH2:10][Br:29]

참가 물질

5

반응물 3

HCID 7187Benzoyl Peroxide2회HCID 67184N-bromobutanimideHCID 767493-Chloro-2-methylanisole

생성물 1

HCID 223274432-(Bromomethyl)-1-chloro-3-methoxybenzene

시약·촉매·용매 1

HCID 5943Carbon Tetrachloride용매

실험 절차

To 13.0 g (84.92 mmol) 3-chloro-2-methylanisole in 80 ml CCl4 at reflux were added 0.4 g dibenzoyl peroxide and then, subsequently and portion-wise, a mixture of 15.2 g N-bromosuccinimide and 0.4 g dibenzoyl peroxide. After completion of reaction the mixture was evaporation-concentrated, the residue was dissolved in dichloromethane, was sequentially washed with water and saturated NaCl solution, was dried over MgSO4, was filtered and again evaporation-concentrated. 20.8 yellow oil.

후처리

  1. customAfter completion of reaction the mixture
  2. concentrationwas evaporation-concentrated
  3. dissolutionthe residue was dissolved in dichloromethane
  4. washwas sequentially washed with water and saturated NaCl solution
  5. dry with materialwas dried over MgSO4
  6. filtrationwas filtered
  7. concentrationagain evaporation-concentrated

출처 및 근거

ORD 기록
ord-64c8ff1a9d2146beb4c4a081d5052a32
출처 데이터셋
uspto-grants-2013_07
특허 번호
US08481576B2

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