Hydrochloric Acid → HCID 178491370, 화합물

HRID 447941

반응식

HRID 447941 반응식
Cl.[CH3:2][O:3][C:4]1[CH:11]=[CH:10][CH:9]=[C:8]([O:12][CH3:13])[C:5]=1[CH2:6][NH2:7].[N-:14]([C:17]#[N:18])[C:15]#[N:16].[Na+]>>[C:15]([NH:14][C:17]([NH:7][CH2:6][C:5]1[C:8]([O:12][CH3:13])=[CH:9][CH:10]=[CH:11][C:4]=1[O:3][CH3:2])=[NH:18])#[N:16]

참가 물질

4

반응물 3

HCID 313Hydrochloric AcidHCID 28008722,6-DimethoxybenzylamineHCID 4350929Sodium dicyanamide

생성물 1

HCID 178491370HCID 178491370, 화합물

실험 절차

15 ml 2N hydrochloric acid were added to 5.0 g (29.9 mmol) 2,6-dimethoxybenzylamine and the aqueous phase was subsequently removed under vacuum. The residue was then dissolved in 50 ml 1-butanol and 2.66 g (29.9 mmol) of sodium dicyanamide were added. The reaction mixture was heated for 5.5 hours at reflux and stirred for 12 hours at room temperature. The precipitate formed was filtered off, was washed with diethylether; 6.81 g.

후처리

  1. customthe aqueous phase was subsequently removed under vacuum
  2. dissolutionThe residue was then dissolved in 50 ml 1-butanol
  3. temperatureThe reaction mixture was heated for 5.5 hours
  4. temperatureat reflux
  5. customThe precipitate formed
  6. filtrationwas filtered off
  7. washwas washed with diethylether

출처 및 근거

ORD 기록
ord-0740ffcdbd084f38a1576fed031345a4
출처 데이터셋
uspto-grants-2013_07
특허 번호
US08481576B2

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