Butyl iodide → 3-Butyl-2,4,5-trimethylthiazol-3-ium iodide

HRID 448019노트

반응식

HRID 448019 반응식
[CH3:1][C:2]1[S:3][C:4]([CH3:8])=[C:5]([CH3:7])[N:6]=1.[CH2:9]([I:13])[CH2:10][CH2:11][CH3:12]>C(#N)C>[I-:13].[CH2:9]([N+:6]1[C:5]([CH3:7])=[C:4]([CH3:8])[S:3][C:2]=1[CH3:1])[CH2:10][CH2:11][CH3:12]

참가 물질

4

반응물 2

HCID 10962Butyl iodideHCID 616532,4,5-Trimethylthiazole

생성물 1

HCID 691655913-Butyl-2,4,5-trimethylthiazol-3-ium iodide

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

A mixture of 2,4,5-trimethylthiazole (1.3 g, 10 mmol) and n-butyl iodide (7.4 g, 40 mmol) in anhydrous acetonitrile (30 mL) was refluxed for 72 hours and then concentrated under reduced pressure to provide the crude thiazolium salt. 1H NMR (300 MHz, DMSO-d6) δ 0.95 (t, J=7 Hz, 3H), 1.39 (sextet, J=7 Hz, 2H), 1.65 (m, 2H), 2.43 (s, 6H), 2.96 (s, 3H), 4.25 (m, 2H).

후처리

  1. temperaturewas refluxed for 72 hours
  2. concentrationconcentrated under reduced pressure

출처 및 근거

ORD 기록
ord-20b9fb863e514c1190cbe561ccf3576c
출처 데이터셋
uspto-grants-2013_07
특허 번호
US08481574B2

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