HCID 66632589, 화합물 → 4-methylnaphthalen-1-amine

HRID 448160노트

반응식

HRID 448160 반응식
[CH3:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[C:5]([N+:12]([O-])=O)=[CH:4][C:3]=1N>C(O)C.[Ni]>[CH3:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[C:5]([NH2:12])=[CH:4][CH:3]=1

참가 물질

4

반응물 1

HCID 66632589HCID 66632589, 화합물

생성물 1

HCID 4311874-methylnaphthalen-1-amine수율 96.9%

시약·촉매·용매 2

HCID 935Nickel촉매HCID 702Ethanol용매

실험 절차

To a solution of 1-methyl-4-nitro-naphthyl-amine (4.0 g, 21 mmol) in ethanol (300 mL) was added Raney-Nickel (4 scoops). The mixture was stirred under H2 (1 atm) for 16 h. The reaction was filtered through a pad of Celite and concentrated. Purification by silica gel flash column chromatography (EtOAc:Hexanes=15:85) provided product (3.2 g, 75%).

후처리

  1. filtrationThe reaction was filtered through a pad of Celite
  2. concentrationconcentrated
  3. customPurification by silica gel flash column chromatography (EtOAc:Hexanes=15:85)

출처 및 근거

ORD 기록
ord-7e4a29393c1e41698fdcc0d878680b42
출처 데이터셋
uspto-grants-2013_07
특허 번호
US08481581B2

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