Water → HCID 20139720, 화합물

HRID 4483노트

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HRID 4483 반응식
[OH-].[Na+].[CH2:3]([C:6]1[CH:7]=[C:8]2[C:14](=[O:15])[N:13]([C:16]([CH:21]([CH3:23])[CH3:22])([CH3:20])[C:17]([NH2:19])=[O:18])[C:12](=O)[C:9]2=[N:10][CH:11]=1)[CH2:4][CH3:5].O>C1(C)C=CC=CC=1>[CH:21]([C:16]1([CH3:20])[N:13]2[C:14](=[O:15])[C:8]3[C:9](=[N:10][CH:11]=[C:6]([CH2:3][CH2:4][CH3:5])[CH:7]=3)[C:12]2=[N:19][C:17]1=[O:18])([CH3:23])[CH3:22]

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5

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HCID 962WaterHCID 14798Sodium HydroxideHCID 20139714alpha-[3-n-propyl-6H-pyrrolo[3,4-b]pyridine-5,7-dione-6-yl]-alpha-isopropyl-alpha-methyl-acetamide

생성물 1

HCID 20139720HCID 20139720, 화합물

시약·촉매·용매 1

HCID 1140Toluene용매

실험 절차

With the simultaneous addition of 0.5 g of powdered sodium hydroxide, a solution of α-[3-n-propyl-6H-pyrrolo[3,4-b]pyridine-5,7-dione-6-yl]-α-isopropyl-α-methyl-acetamide (m.p.: 82° C.) in 100 ml of toluene is heated under reflux for 2 hours in a water separator. After the reaction solution has cooled, it is filtered through silica gel and the filtrate is washed with ethyl acetate and then concentrated by evaporation. The residue is recrystallised from ethyl acetate/petroleum ether, affording 13.1 g of the title compound which melts at 116° C.

후처리

  1. temperatureAfter the reaction solution has cooled
  2. filtrationit is filtered through silica gel
  3. washthe filtrate is washed with ethyl acetate
  4. concentrationconcentrated by evaporation
  5. customThe residue is recrystallised from ethyl acetate/petroleum ether

출처 및 근거

ORD 기록
ord-a5f8cf3706fb4e88af4fdf400f66f3e5
출처 데이터셋
uspto-grants-1988_02
특허 번호
US04726838

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