Potassium Carbonate → 2-(1-Methoxycarbonylethoxy)benzenesulfonamide

HRID 4485

반응식

HRID 4485 반응식
[OH:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[S:8]([NH2:11])(=[O:10])=[O:9].C(=O)([O-])[O-].[K+].[K+].Br[CH:19]([CH3:24])[C:20]([O:22][CH3:23])=[O:21]>C(#N)C>[CH3:23][O:22][C:20]([CH:19]([O:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[S:8]([NH2:11])(=[O:9])=[O:10])[CH3:24])=[O:21]

참가 물질

5

반응물 3

HCID 11430Potassium CarbonateHCID 95576Methyl 2-bromopropionateHCID 6375462-Hydroxybenzene-1-sulfonamide

생성물 1

HCID 221528372-(1-Methoxycarbonylethoxy)benzenesulfonamide수율 80.7%

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

34.6 g of 2-hydroxybenzenesulfonamide and 55.3 g of potassium carbonate are added to 800 ml of acetonitrile. With efficient stirring, 33.4 g of methyl 2-bromopropionate are added dropwise over 10 minutes and the suspension is then heated for 5 hours to 45° C. After the reaction mixture has cooled, the precipitated salts are isolated and the filtrate is concentrated in vacuo. The residue is recrystallised from ethanol, affording 41.8 g of 2-(1-methoxycarbonylethoxy)- benzenesulfonamide with a melting point of 140°-142° C.

후처리

  1. temperaturethe suspension is then heated for 5 hours to 45° C
  2. temperatureAfter the reaction mixture has cooled
  3. customthe precipitated salts are isolated
  4. concentrationthe filtrate is concentrated in vacuo
  5. customThe residue is recrystallised from ethanol

출처 및 근거

ORD 기록
ord-580394b4ef7a438bb6f3a79f841eee23
출처 데이터셋
uspto-grants-1988_02
특허 번호
US04726836

연결된 노트

불러오는 중…