Ammonium formate → 2-Phenylglycine
반응식
C(O[C:4](=O)[C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1)=O.[CH:12]([O-:14])=[O:13].[NH4+:15]>[Ir].CO>[CH:8]1[CH:7]=[CH:6][C:5]([CH:4]([NH2:15])[C:12]([OH:14])=[O:13])=[CH:10][CH:9]=1참가 물질
5
반응 조건
- 온도
- 60 °C
실험 절차
751 mg (5.0 mmol) of benzoyl formate (MW: 150.13), 946 mg (15.0 mmol) of ammonium formate (MW: 63.06), and 5.90 mg (0.01 mmol, S/C=500) of the iridium catalyst Ir-7 (MW: 590.13) were introduced in a 20-mL Schlenk tube and subjected to argon-gas replacement. 5 mL of dehydrated methanol was added and the mixture was stirred while heating at 60° C. for 1.5 hr. After distillation of the solvent, a crystal was collected by filtration, washed with methanol, dried under reduced pressure to give 718 mg of DL-2-phenylglycine (95% yield).
후처리
- distillationAfter distillation of the solvent
- filtrationa crystal was collected by filtration
- washwashed with methanol
- customdried under reduced pressure
출처 및 근거
- ORD 기록
- ord-d1fafd6f22294d248c9f66b46250b11b
- 출처 데이터셋
- uspto-grants-2013_07
- 특허 번호
- US08481735B2
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