Ammonium formate → 2-Phenylglycine

HRID 448653

반응식

HRID 448653 반응식
C(O[C:4](=O)[C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1)=O.[CH:12]([O-:14])=[O:13].[NH4+:15]>[Ir].CO>[CH:8]1[CH:7]=[CH:6][C:5]([CH:4]([NH2:15])[C:12]([OH:14])=[O:13])=[CH:10][CH:9]=1

참가 물질

5

반응물 2

HCID 2723923Ammonium formateHCID 6422010HCID 6422010, 화합물

생성물 1

HCID 38662-Phenylglycine수율 95%

시약·촉매·용매 2

HCID 23924Iridium촉매HCID 887Methanol용매

반응 조건

온도
60 °C

실험 절차

751 mg (5.0 mmol) of benzoyl formate (MW: 150.13), 946 mg (15.0 mmol) of ammonium formate (MW: 63.06), and 5.90 mg (0.01 mmol, S/C=500) of the iridium catalyst Ir-7 (MW: 590.13) were introduced in a 20-mL Schlenk tube and subjected to argon-gas replacement. 5 mL of dehydrated methanol was added and the mixture was stirred while heating at 60° C. for 1.5 hr. After distillation of the solvent, a crystal was collected by filtration, washed with methanol, dried under reduced pressure to give 718 mg of DL-2-phenylglycine (95% yield).

후처리

  1. distillationAfter distillation of the solvent
  2. filtrationa crystal was collected by filtration
  3. washwashed with methanol
  4. customdried under reduced pressure

출처 및 근거

ORD 기록
ord-d1fafd6f22294d248c9f66b46250b11b
출처 데이터셋
uspto-grants-2013_07
특허 번호
US08481735B2

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