Thiourea → HCID 178496713, 화합물

HRID 448662노트

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HRID 448662 반응식
[NH2:1][C:2]1[N:3]=[C:4](Cl)[C:5]2[CH:10]=[CH:9][N:8]([C@@H:11]3[O:18][C@H:17]([CH2:19][OH:20])[C@@H:15]([OH:16])[C@H:12]3[O:13][CH3:14])[C:6]=2[N:7]=1.NC(N)=[S:24]>CCO>[NH2:1][C:2]1[NH:3][C:4](=[S:24])[C:5]2[CH:10]=[CH:9][N:8]([C@@H:11]3[O:18][C@H:17]([CH2:19][OH:20])[C@@H:15]([OH:16])[C@H:12]3[O:13][CH3:14])[C:6]=2[N:7]=1

참가 물질

4

반응물 2

HCID 2723790ThioureaHCID 9836515HCID 9836515, 화합물

생성물 1

HCID 178496713HCID 178496713, 화합물

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

A solution of the compound from Example 11, Step C (1.5 g, 5 mmol), thiourea (0.4 g, 5.2 mmol.) in abs. EtOH was refluxed for 16 hrs. The solution was evaporated and the resulting oil chromatographed on silica gel (EtOAc/MeOH:9/1) to afford the desired product as a foam.

후처리

  1. customThe solution was evaporated
  2. customthe resulting oil chromatographed on silica gel (EtOAc/MeOH:9/1)

출처 및 근거

ORD 기록
ord-e0a5c16e8e8d42898cd0ff5067a0096b
출처 데이터셋
uspto-grants-2013_07
특허 번호
US08481712B2

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