Dimethylformamide → 4-Bromo-2,2-diphenylbutyric chloride

HRID 448809

반응식

HRID 448809 반응식
[Br:1][CH2:2][CH2:3][C:4]([C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)[C:5](O)=[O:6].S(Cl)([Cl:22])=O.CN(C=O)C>C(Cl)(Cl)Cl>[Br:1][CH2:2][CH2:3][C:4]([C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)[C:5]([Cl:22])=[O:6]

참가 물질

5

반응물 3

HCID 6228DimethylformamideHCID 24386Thionyl Chloride2회HCID 27569594-Bromo-2,2-diphenylbutyric acid

생성물 1

HCID 222500664-Bromo-2,2-diphenylbutyric chloride

시약·촉매·용매 1

HCID 6212Chloroform용매

실험 절차

4-Bromo-2,2-diphenylbutyric acid (D) (Aldrich Chemical Company, Inc.) (23 g, 72 mmol) was suspended in chloroform (150 mL), and thionyl chloride (20 mL) was added dropwise. After addition of thionyl chloride, DMF (0.2 mL) was added, and the resulting solution was heated at reflux for 4 hours. The reaction mixture was then concentrated under reduced pressure to provide 4-bromo-2,2-diphenylbutyric acid chloride (E) as a pale yellow oil that was used for next step without further purification.

후처리

  1. additionwas added
  2. temperaturethe resulting solution was heated
  3. temperatureat reflux for 4 hours
  4. concentrationThe reaction mixture was then concentrated under reduced pressure

출처 및 근거

ORD 기록
ord-220ebb96453644fca7e51a9f5a6e1e52
출처 데이터셋
uspto-grants-2013_07
특허 번호
US08481743B2

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