Benzoyl chloride → Benzamide, N-cyano-
반응식
[C:1](Cl)(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[N:10]#[C:11][NH2:12].[Na]>C(OCC)C>[C:1]([NH:12][C:11]#[N:10])(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1참가 물질
4
실험 절차
Benzoylcyanamide was prepared by the addition of benzoyl chloride (6.33 g, 0.045 mol) in 100 ml of diethyl ether to a suspension of monosodium cyanamide (5.76 g, 0.090 mol) in 100 ml of ether at 4° C. The reaction was stirred overnight at room temperature and the pale yellow solid which formed was collected and dissolved in water. On acidification of the solution to pH 1, a precipitate formed which was collected and recrystallized from ethyl acetate (EtOAc)/petroleum ether (30-60° C) to give 2 (5.89 g, 89.7% yield), mp 140°-142° C. [reported mp 139°-140° C⟧ Anal. Calcd for C8H6H2O: C, 65.75; H, 4.11; N, 19.18. Found: C, 65.79; H, 4.35; N, 19.04.
후처리
- customthe pale yellow solid which formed
- customwas collected
- dissolutiondissolved in water
- customOn acidification of the solution to pH 1, a precipitate formed which
- customwas collected
- customrecrystallized from ethyl acetate (EtOAc)/petroleum ether (30-60° C)
출처 및 근거
- ORD 기록
- ord-42d1b3eddfb84c7aa01824183c097731
- 출처 데이터셋
- uspto-grants-1988_02
- 특허 번호
- US04726941
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