4-Nitro-1,3-benzenediamine → 4-Bromo-6-nitro-benzene-1,3-diamine dihydrobromide salt
반응식
[Br:1]Br.[N+:3]([C:6]1[CH:11]=[CH:10][C:9]([NH2:12])=[CH:8][C:7]=1[NH2:13])([O-:5])=[O:4]>O1CCOCC1>[BrH:1].[BrH:1].[Br:1][C:10]1[CH:11]=[C:6]([N+:3]([O-:5])=[O:4])[C:7]([NH2:13])=[CH:8][C:9]=1[NH2:12]참가 물질
4
실험 절차
The reaction scheme (CCLXIX) illustrates a synthetic process rthat included dropwise adding of 6.4 g bromine (40 mmol) to a solution of 4-nitrobenzene-1,3-diamine (5.56 g, 36.3 mmol), in 50 mL 1,4-dioxane, followed by stirring the solution was room temperature for 16 h. The yellow precipitate was isolated by filtration, washed with 1,4-dioxane (30 mL) and dried in vacuo to give 4-bromo-6-nitro-benzene-1,3-diamine dihydrobromide salt designated on the reaction scheme (CCLXIX) as compound 13 (8 g, 95%).
후처리
- customThe reaction scheme (CCLXIX)
- customThe yellow precipitate was isolated by filtration
- washwashed with 1,4-dioxane (30 mL)
- customdried in vacuo
출처 및 근거
- ORD 기록
- ord-c53e1a6c5ab04b069858c1509f90f74a
- 출처 데이터셋
- uspto-grants-2013_07
- 특허 번호
- US08481536B2
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