Hydrochloric Acid → Hydrochloric Acid

HRID 449311노트

반응식

HRID 449311 반응식
[ClH:1].[NH2:2][C:3]1[N:8]=[C:7]([C:9]2[CH:18]=[C:17]3[C:12]([CH2:13][CH2:14][N:15](C(OC(C)(C)C)=O)[CH2:16]3)=[CH:11][CH:10]=2)[CH:6]=[C:5]([N:26]2[CH2:31][CH2:30][N:29]([CH3:32])[CH2:28][CH2:27]2)[N:4]=1>O1CCOCC1.CO>[CH3:32][N:29]1[CH2:28][CH2:27][N:26]([C:5]2[CH:6]=[C:7]([C:9]3[CH:18]=[C:17]4[C:12]([CH2:13][CH2:14][NH:15][CH2:16]4)=[CH:11][CH:10]=3)[N:8]=[C:3]([NH2:2])[N:4]=2)[CH2:31][CH2:30]1.[ClH:1]

참가 물질

6

반응물 2

HCID 313Hydrochloric AcidHCID 59496680tert-butyl 7-[2-amino-6-(4-methylpiperazin-1-yl)pyrimidin-4-yl]-3,4-dihydroisoquinoline-2(1H)-carboxylate

생성물 2

HCID 313Hydrochloric AcidHCID 497794384-(4-Methylpiperazin-1-yl)-6-(1,2,3,4-tetrahydroisoquinolin-7-yl)pyrimidin-2-amine

시약·촉매·용매 2

HCID 887Methanol용매HCID 312751,4-Dioxane용매

실험 절차

6 mL of 4N HCl in dioxane was added to a solution of tert-butyl 7-[2-amino-6-(4-methylpiperazin-1-yl)pyrimidin-4-yl]-3,4-dihydroisoquinoline-2(1H)-carboxylate (0.90 g, 2.1 mmol) in methanol (5 mL). The mixture was stirred at r.t. for 2 h. The mixture was concentrated under reduced pressure. The residue was washed with ether and dried under vacuum to afford the desired product as an HCl salt (0.83 g). Analytic LCMS (M+H)+: m/z=325.4.

후처리

  1. concentrationThe mixture was concentrated under reduced pressure
  2. washThe residue was washed with ether
  3. customdried under vacuum

출처 및 근거

ORD 기록
ord-76982313218742ccb3a1a3f9dd696804
출처 데이터셋
uspto-grants-2013_07
특허 번호
US08481732B2

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