Ammonia → 5-{2-[7-[2-amino-6-(4-methylpiperazin-1-yl)pyrimidin-4-yl]-3,4-dihydroisoquinolin-2(1H)-yl]-2-oxoethyl}nicotinonitrile

반응식

Br[C:2]1[CH:3]=[C:4]([CH2:8][C:9]([N:11]2[CH2:20][CH2:19][C:18]3[C:13](=[CH:14][C:15]([C:21]4[CH:26]=[C:25]([N:27]5[CH2:32][CH2:31][N:30]([CH3:33])[CH2:29][CH2:28]5)[N:24]=[C:23]([NH2:34])[N:22]=4)=[CH:16][CH:17]=3)[CH2:12]2)=[O:10])[CH:5]=[N:6][CH:7]=1.[CH3:35][N:36]1CCCC1=O.N>[C-]#N.[Zn+2].[C-]#N.CC(C)([P](C(C)(C)C)([Pd][P](C(C)(C)C)(C(C)(C)C)C(C)(C)C)C(C)(C)C)C.[Zn]>[NH2:34][C:23]1[N:22]=[C:21]([C:15]2[CH:14]=[C:13]3[C:18]([CH2:19][CH2:20][N:11]([C:9](=[O:10])[CH2:8][C:4]4[CH:5]=[N:6][CH:7]=[C:2]([CH:3]=4)[C:35]#[N:36])[CH2:12]3)=[CH:17][CH:16]=2)[CH:26]=[C:25]([N:27]2[CH2:32][CH2:31][N:30]([CH3:33])[CH2:29][CH2:28]2)[N:24]=1