Hydrochloric Acid → 2-(6-chloropyridin-3-yl)-N-ethylpropan-2-amine
반응식
[Cl:1][C:2]1[N:7]=[CH:6][C:5]([C:8]([NH:11][C:12](=O)[CH3:13])([CH3:10])[CH3:9])=[CH:4][CH:3]=1.Cl>C1COCC1>[Cl:1][C:2]1[N:7]=[CH:6][C:5]([C:8]([NH:11][CH2:12][CH3:13])([CH3:9])[CH3:10])=[CH:4][CH:3]=1참가 물질
4
실험 절차
N-(2-(6-chloropyridin-3-yl)propan-2-yl)acetamide (11.3 g, 53.1 mmol, Eq: 1.00) was dissolved in anhydrous THF (350 ml) and refluxed. BMS (2M in THF) (53.1 ml, 106 mmol, Eq: 2) was added dropwise to the solution and refluxed over night. Conc. HCl solution (15 ml) was gently added to the refluxed reaction mixture and stirred for 1 hr. The reaction mixture was concentrated in vacuo.
후처리
- temperaturerefluxed
- temperaturerefluxed over night
- concentrationThe reaction mixture was concentrated in vacuo
출처 및 근거
- ORD 기록
- ord-876ca2c6029a488da2cf414671c55155
- 출처 데이터셋
- uspto-grants-2013_07
- 특허 번호
- US08481540B2
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