Lamotrigine → 6-(2,3-Dichlorophenyl)-1,2,4-triazine-3,5-diamine;2-hydroxybutanedioate

HRID 449792

반응식

HRID 449792 반응식
[CH:1]1[CH:6]=[C:5]([Cl:7])[C:4]([Cl:8])=[C:3]([C:9]2[N:14]=[N:13][C:12]([NH2:15])=[N:11][C:10]=2[NH2:16])[CH:2]=1.[Na+].[C:18]([O-:26])(=[O:25])[CH:19]([CH2:21][C:22]([O-:24])=[O:23])[OH:20].[Na+]>CO>[CH:1]1[CH:6]=[C:5]([Cl:7])[C:4]([Cl:8])=[C:3]([C:9]2[N:14]=[N:13][C:12]([NH2:15])=[N:11][C:10]=2[NH2:16])[CH:2]=1.[C:18]([O-:26])(=[O:25])[CH:19]([CH2:21][C:22]([O-:24])=[O:23])[OH:20]

참가 물질

4

반응물 2

HCID 3878LamotrigineHCID 8736Malic acid, disodium salt

생성물 1

HCID 866323236-(2,3-Dichlorophenyl)-1,2,4-triazine-3,5-diamine;2-hydroxybutanedioate

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

20 mg of lamotrigine was dissolved in 2 ml of methanol, 12 mg of malic acid sodium salt was added to the solution to form a single solution. The solution was then allowed to stand for several hours to effect the slow evaporation of solvent. The solids gathered were stored in screw cap vials for subsequent analysis.

후처리

  1. customto form a single solution
  2. waitto stand for several hours
  3. customthe slow evaporation of solvent
  4. customcap vials for subsequent analysis

출처 및 근거

ORD 기록
ord-1bfa01b5902049028c09a97c1103eb66
출처 데이터셋
uspto-grants-2013_07
특허 번호
US08486927B2

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