Hydrazine → Aminotetrahydrocyclopenta[b]indole

HRID 449823노트

반응식

[CH2:1]1[C:12]2[CH:4]([N:5]=[C:6]3[C:11]=2[CH:10]=[CH:9][CH:8]=[CH:7]3)[CH2:3][CH2:2]1.[NH2:13]N.O.NN>>[NH2:13][CH:1]1[C:12]2[CH:4]([N:5]=[C:6]3[C:11]=2[CH:10]=[CH:9][CH:8]=[CH:7]3)[CH2:3][CH2:2]1

참가 물질

반응물 3

HCID 9321Hydrazine

HCID 24654Hydrazine hydrate (1:1)

HCID 66869719Tetrahydrocyclopent(b)indole

생성물 1

HCID 66933239Aminotetrahydrocyclopenta[b]indole

실험 절차

In Step B, the phthalimide group of the tetrahydrocyclopenta[b]indole of formula (8) is cleaved with hydrazine or hydrazine hydrate to provide an aminotetrahydrocyclopenta[b]indole of formula (9). Preferred conditions use tetrahydrofuran/ethanol in a mixture of about 20/1 by volume at a temperature of about 40 to 70° C., for 1 to 12 hours. The resulting phthalhydrazide is removed by filtration and the product isolated by concentration of the filtrate.

출처 및 근거

ORD 기록: ord-62b7186df0464acabdef425ba0309260
출처 데이터셋: uspto-grants-2013_07
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08486943B2

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