Dimethylamine → HCID 67128887, 화합물

HRID 449923

반응식

HRID 449923 반응식
[Cl:1][C:2]1[CH:10]=[C:9]([C:11](O)=[O:12])[CH:8]=[C:7]([Cl:14])[C:3]=1[C:4]([OH:6])=[O:5].C1N=[CH:18][N:17](C(N2C=NC=C2)=O)[CH:16]=1.CNC>ClC1CC(C(C)C)CCC1(Cl)C>[Cl:1][C:2]1[CH:10]=[C:9]([C:11](=[O:12])[N:17]([CH3:18])[CH3:16])[CH:8]=[C:7]([Cl:14])[C:3]=1[C:4]([OH:6])=[O:5]

참가 물질

5

반응물 3

HCID 674DimethylamineHCID 39047Benzenedicarboxylic acid, dichloro-HCID 682631,1'-Carbonyldiimidazole

생성물 1

HCID 67128887HCID 67128887, 화합물

시약·촉매·용매 1

HCID 21946423Dichloromenthane용매

실험 절차

To a solution of 2,6-dichloroterephthalic acid (100 mg, 0.46 mmol) in dichloromenthane was added CDI (62 mg, 0.46 mmol) in one portion. The reaction mixture was stirred at room temperature for 1.5 hours and then dimethyl amine (1.0 M in THF, 2 mL, 2.0 mmol) was added. The reaction was concentrated under reduced pressure to give the crude 2,6-dichloro-4-(dimethylcarbamoyl)benzoic acid, which was used in the next step without further purification. 1H NMR (500 MHz, DMSO-d6): δ 14.35 (s, 1H), 7.56 (s, 2H), 2.97 (s, 3H), 2.89 (s, 3H).

후처리

  1. concentrationThe reaction was concentrated under reduced pressure

출처 및 근거

ORD 기록
ord-763c3c867a3e45b58807a5388d5794a5
출처 데이터셋
uspto-grants-2013_07
특허 번호
US08486950B2

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