Hydrochloric Acid → (Tetrahydro-2H-pyran-3-yl)hydrazine hydrochloride
반응식
[O:1]1[CH2:6][CH2:5][CH2:4][CH:3]([NH:7][NH:8]C(OC(C)(C)C)=O)[CH2:2]1.C(OCC)(=O)C.[ClH:22]>ClCCl>[ClH:22].[O:1]1[CH2:6][CH2:5][CH2:4][CH:3]([NH:7][NH2:8])[CH2:2]1참가 물질
5
실험 절차
(±)-tert-Butyl 2-(tetrahydro-2H-pyran-3-yl)hydrazinecarboxylate (216 mg, 1.00 mmol) was dissolved in dichloromethane (10 mL) and ethyl acetate (10 mL) and cooled to 0° C. The mixture was saturated with gaseous hydrogen chloride, warmed to ambient temperature and stirred for 1 hour. The mixture was concentrated in vacuo and the residue was concentrated with toluene (2×20 mL) to afford the titled compound.
후처리
- concentrationThe mixture was concentrated in vacuo
- concentrationthe residue was concentrated with toluene (2×20 mL)
출처 및 근거
- ORD 기록
- ord-604b4dbbb73f4ad292474f23b2ceed00
- 출처 데이터셋
- uspto-grants-2013_07
- 특허 번호
- US08486946B2
반응 노트
불러오는 중…