Ethanol → Alanine, 2-methyl-, ethyl ester

HRID 450034

반응식

HRID 450034 반응식
[NH2:1][C:2]([CH3:7])([CH3:6])[C:3]([OH:5])=[O:4].S(Cl)(Cl)=O.[CH2:12](O)[CH3:13]>>[CH2:12]([O:4][C:3](=[O:5])[C:2]([NH2:1])([CH3:7])[CH3:6])[CH3:13]

참가 물질

4

반응물 3

HCID 702EthanolHCID 6119Aminoisobutyric acidHCID 24386Thionyl Chloride

생성물 1

HCID 70683Alanine, 2-methyl-, ethyl ester수율 63%

반응 조건

온도
0 °C

실험 절차

2-Amino-2-methyl-propionic acid (1.0 g, 9.69 mmol) was dissolved in ethanol (15 ml) and cooled to 0° C. Thionyl chloride (1.7 g, 14.53 mmol, 1.5 eq) was added to the reaction mixture, which was then heated to reflux overnight. The solvent was evaporated and the residue was partitioned between water and ethyl acetate. The organic layer was concentrated and dried to give 2-amino-2-methyl-propionic acid ethyl ester (0.8 g, 63%). The crude compound was used in the next stage without purification.

후처리

  1. temperaturewas then heated
  2. temperatureto reflux overnight
  3. customThe solvent was evaporated
  4. customthe residue was partitioned between water and ethyl acetate
  5. concentrationThe organic layer was concentrated
  6. customdried

출처 및 근거

ORD 기록
ord-b9501f6ba7be4d5b99e63345d16d1dfc
출처 데이터셋
uspto-grants-2013_07
특허 번호
US08486962B2

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