Water → 1H-Indole, 2,3-dihydro-1-methyl-5-nitro-

HRID 450044

반응식

HRID 450044 반응식
[N+:1]([C:4]1[CH:5]=[C:6]2[C:10](=[CH:11][CH:12]=1)[NH:9][CH2:8][CH2:7]2)([O-:3])=[O:2].[OH-].[K+].[CH3:15]I.O>CC(C)=O>[CH3:15][N:9]1[C:10]2[C:6](=[CH:5][C:4]([N+:1]([O-:3])=[O:2])=[CH:12][CH:11]=2)[CH2:7][CH2:8]1

참가 물질

6

반응물 4

HCID 962WaterHCID 6328Methyl iodideHCID 14797Potassium HydroxideHCID 362195-Nitroindoline

생성물 1

HCID 1677381H-Indole, 2,3-dihydro-1-methyl-5-nitro-수율 92.2%

시약·촉매·용매 1

HCID 180Acetone용매

실험 절차

To a solution of 5-nitro-2,3-dihydro-1H-indole (1 g, 6.09 mmol) in acetone (12 ml) was added powdered potassium hydroxide (1.7 g, 30.45 mmol), followed by methyl iodide (1.2 g, 9.14 mmol) and stirred overnight at ambient temperature. The solvent was evaporated under vacuum to give a residue, to which water was added and the product extracted with ethyl acetate. Drying and concentration of the organic layer yielded 1-methyl-5-nitro-2,3-dihydro-1H-indole (1 g, 92%) as solid.

후처리

  1. customThe solvent was evaporated under vacuum
  2. customto give a residue
  3. extractionthe product extracted with ethyl acetate
  4. customDrying

출처 및 근거

ORD 기록
ord-d7a933c1cbea496898453122ccff6b34
출처 데이터셋
uspto-grants-2013_07
특허 번호
US08486962B2

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