Hydrochloric Acid → 4-(1,3-Oxazol-5-yl)aniline

HRID 450097

반응식

HRID 450097 반응식
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([C:10]2[O:14][CH:13]=[N:12][CH:11]=2)=[CH:6][CH:5]=1)([O-])=O.[Sn].Cl>C(O)C>[O:14]1[C:10]([C:7]2[CH:6]=[CH:5][C:4]([NH2:1])=[CH:9][CH:8]=2)=[CH:11][N:12]=[CH:13]1

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 27370685-(4-Nitrophenyl)-1,3-oxazoleHCID 5352426Tin atom

생성물 1

HCID 5177474-(1,3-Oxazol-5-yl)aniline수율 91.2%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

To a solution of 5-(4-nitro-phenyl)-oxazole (500 mg, 2.6 mmol) in ethanol (10 ml) was added tin (620 mg, 5.2 mmol), followed by dropwise addition of concentrated hydrochloric acid (1 ml) and then the reaction was stirred at room temperature for 2 hr. The reaction mixture was filtered and the filtrate evaporated to dryness. The resultant residue was diluted with water (10 ml), basified with saturated bicarbonate solution, then extracted with ethyl acetate. The organic layer was separated, washed with water, dried and concentrated to dryness to yield 4-oxazol-5-yl-phenylamine (380 mg, 90%) as solid.

후처리

  1. filtrationThe reaction mixture was filtered
  2. customthe filtrate evaporated to dryness
  3. additionThe resultant residue was diluted with water (10 ml)
  4. extractionextracted with ethyl acetate
  5. customThe organic layer was separated
  6. washwashed with water
  7. customdried
  8. concentrationconcentrated to dryness

출처 및 근거

ORD 기록
ord-41409a87bf4d48bba398abb33b6b2a0f
출처 데이터셋
uspto-grants-2013_07
특허 번호
US08486962B2

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