Hydrochloric Acid → 4-(2-Hydroxyethyl)cyclohexan-1-one

HRID 45012

반응식

HRID 45012 반응식
[O:1]1[C:5]2([CH2:10][CH2:9][CH:8]([CH2:11][CH2:12][OH:13])[CH2:7][CH2:6]2)OCC1.C1COCC1.Cl.C([O-])(O)=O.[Na+]>CC(C)=O>[OH:13][CH2:12][CH2:11][CH:8]1[CH2:9][CH2:10][C:5](=[O:1])[CH2:6][CH2:7]1

참가 물질

6

반응물 4

HCID 313Hydrochloric AcidHCID 8028TetrahydrofuranHCID 516892Sodium BicarbonateHCID 118054582-(1,4-Dioxaspiro(4.5)decan-8-yl)ethan-1-ol

생성물 1

HCID 157003924-(2-Hydroxyethyl)cyclohexan-1-one

시약·촉매·용매 1

HCID 180Acetone용매

반응 조건

온도
25 °C

실험 절차

2-(1,4-Dioxaspiro[4.5]dec-8-yl)ethanol (2.70 g, 0.0145 mol) was dissolved in acetone (10.00 mL) and THF (10.00 mL) and 6.00 M HCl (6.00 mL) was added. The reaction was stirred at 25° C. for 16 hours, neutralized with NaHCO3 solution and was then extracted with ethyl acetate. The organic extracts were washed with water, and with saturated NaCl, then dried (MgSO4) and concentrated in vacuo. The crude product was used in the next reaction without further purification. 1H NMR(CDCl3): 3.75 (m, 2H), 2.36 (m, 4H), 1.20-2.13 (m, 7H).

후처리

  1. extractionwas then extracted with ethyl acetate
  2. washThe organic extracts were washed with water
  3. dry with materialwith saturated NaCl, then dried (MgSO4)
  4. concentrationconcentrated in vacuo
  5. customThe crude product was used in the next reaction without further purification

출처 및 근거

ORD 기록
ord-ab5b9732bfe747209e2c3cbda0178206
출처 데이터셋
uspto-grants-2013_09
특허 번호
US08541425B2

연결된 노트

불러오는 중…