Ammonium formate → 2-isopropoxypyridin-3-amine
반응식
[CH:1]([O:4][C:5]1[C:10]([N+:11]([O-])=O)=[CH:9][CH:8]=[CH:7][N:6]=1)([CH3:3])[CH3:2].C([O-])=O.[NH4+]>C(O)C.[OH-].[OH-].[Pd+2]>[CH:1]([O:4][C:5]1[C:10]([NH2:11])=[CH:9][CH:8]=[CH:7][N:6]=1)([CH3:3])[CH3:2]참가 물질
5
반응 조건
- 온도
- 90 °C
실험 절차
Palladium hydroxide on carbon (20%, 0.076 g, 0.54 mmol) was added into a solution of 2-iso-propoxy-3-nitro-pyridine (1.97 g, 10.8 mmol) and ammonium formate (3.40 g, 54.0 mmol) in ethanol (100 mL) at ambient temperature. The solution was stirred for 2 hours at 90° C., cooled to ambient temperature, filtered through Celite and washed with MeOH. The filtrate was concentrated in vacuo and triturated from diethyl ether to yield brown oil which was used in the next step without further purification.
후처리
- temperaturecooled to ambient temperature
- filtrationfiltered through Celite
- washwashed with MeOH
- concentrationThe filtrate was concentrated in vacuo
- customtriturated from diethyl ether
- customto yield brown oil which
- customwas used in the next step without further purification
출처 및 근거
- ORD 기록
- ord-38b385b86d064a22905507dafa8eb245
- 출처 데이터셋
- uspto-grants-2013_07
- 특허 번호
- US08486953B2
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