참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Acetonitrile | HCID 6342 | — |
| 반응물 | 2,3-Dihydro-1h-inden-2-yl methanesulfonate | HCID 255221 | — |
| 촉매 | Tetraethylammonium cyanide | HCID 3014735 | — |
| 생성물 | 2,3-Dihydro-1H-indene-2-carbonitrile | HCID 23239618 | 52% |
반응 단계
A mixture of methanesulfonic acid indan-2-yl ester (18.65 g, 87.9 mmol) and tetraethylammonium cyanide (15.10 g) in acetonitrile (180 mL) was heated to 55° C. for 5 hours, cooled and concentrated. The residue was partitioned between ethyl acetate and water, and the organic phase separated. This was dried over MgSO4 and the filtered solution was concentrated and then separated by column chromatography (dichloromethane:ethyl acetate, 6:1-1:1) to give the product as a red solid (6.51 g, 52%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US08486984B2 |
|---|
| 출처 데이터셋 | uspto-grants-2013_07 |
|---|
| ORD ID | ord-b09be4f86e70459ba16dd2d42dc4a312 |
|---|
| 출처 메모 | uspto-grants-2013_07 |
|---|
