Hydrazine hydrate (1:1) → tert-butyl 1-(2-aminoethyl)-1H-pyrrole-3-carboxylate

HRID 450769노트

반응식

HRID 450769 반응식
O=C1C2C(=CC=CC=2)C(=O)[N:3]1[CH2:12][CH2:13][N:14]1[CH:18]=[CH:17][C:16]([C:19]([O:21][C:22]([CH3:25])([CH3:24])[CH3:23])=[O:20])=[CH:15]1.O.NN>C(O)C>[NH2:3][CH2:12][CH2:13][N:14]1[CH:18]=[CH:17][C:16]([C:19]([O:21][C:22]([CH3:25])([CH3:24])[CH3:23])=[O:20])=[CH:15]1

참가 물질

4

반응물 2

HCID 24654Hydrazine hydrate (1:1)HCID 59478522tert-butyl 1-[2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)ethyl]-1H-pyrrole-3-carboxylate

생성물 1

HCID 59479135tert-butyl 1-(2-aminoethyl)-1H-pyrrole-3-carboxylate수율 105.5%

시약·촉매·용매 1

HCID 702Ethanol용매

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온도
70 °C

실험 절차

A mixture of 660 mg of tert-butyl 1-[2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)ethyl]-1H-pyrrole-3-carboxylate, 194 mg of hydrazine monohydrate, and 19 ml of ethanol was stirred at 70° C. for 12 hours. The reaction solution was left to be cooled and the insoluble material was then separated by filtration. The filtrate was concentrated under reduced pressure to obtain 430 mg of tert-butyl 1-(2-aminoethyl)-1H-pyrrole-3-carboxylate as a yellow oily substance.

후처리

  1. waitThe reaction solution was left
  2. temperatureto be cooled
  3. customthe insoluble material was then separated by filtration
  4. concentrationThe filtrate was concentrated under reduced pressure

출처 및 근거

ORD 기록
ord-7bf28f2334514824b918bf06c185bf08
출처 데이터셋
uspto-grants-2013_07
특허 번호
US08486970B2

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