Iodoethane → 3-Amino-5-chloro-2-(2-ethoxybenzoyl)-benzofuran

HRID 450840노트

반응식

HRID 450840 반응식
C(=O)([O-])[O-].[K+].[K+].[NH2:7][C:8]1[C:12]2[CH:13]=[C:14]([Cl:17])[CH:15]=[CH:16][C:11]=2[O:10][C:9]=1[C:18](=[O:26])[C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][C:20]=1[OH:25].[CH2:27](I)[CH3:28]>CN(C=O)C.C(OCC)(=O)C>[NH2:7][C:8]1[C:12]2[CH:13]=[C:14]([Cl:17])[CH:15]=[CH:16][C:11]=2[O:10][C:9]=1[C:18](=[O:26])[C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][C:20]=1[O:25][CH2:27][CH3:28]

참가 물질

6

반응물 3

HCID 6340IodoethaneHCID 11430Potassium CarbonateHCID 587073613-Amino-5-chloro-2-(2-hydroxybenzoyl)-benzofuran

생성물 1

HCID 587073663-Amino-5-chloro-2-(2-ethoxybenzoyl)-benzofuran

시약·촉매·용매 2

HCID 6228Dimethylformamide용매HCID 8857Ethyl Acetate용매

반응 조건

온도
60 °C

실험 절차

A suspension of potassium carbonate (0.056 g, 0.4 mmol), 3-amino-5-chloro-2-(2-hydroxybenzoyl)-benzofuran (0.05 g, 0.4 mmol) and ethyl iodide (0.05 g, 0.34 mmol) in dry DMF is stirred at 60° C. for 2 h. The resulting mixture is diluted with ethyl acetate and washed with water. Drying over sodium sulfate, filtering, evaporating the solvent and purification of the residue by silicagel column chromatography yields the title compound, having a m.p. of 114-115° C.

후처리

  1. washwashed with water
  2. dry with materialDrying over sodium sulfate
  3. filtrationfiltering
  4. customevaporating
  5. customthe solvent and purification of the residue by silicagel column chromatography

출처 및 근거

ORD 기록
ord-16520b04eab941f4a7e5c566c4fd38a6
출처 데이터셋
uspto-grants-2013_07
특허 번호
US08486996B2

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