1-Ethynylcyclohexene → 1-(4-Cyclohex-1-enylethynyl-3-methoxy-phenyl)ethanone

HRID 451260

반응식

HRID 451260 반응식
[C:1]([C:4]1[CH:9]=[CH:8][C:7](OS(C2C=CC(C)=CC=2)(=O)=O)=[C:6]([O:21][CH3:22])[CH:5]=1)(=[O:3])[CH3:2].[C:23]([C:25]1[CH2:30][CH2:29][CH2:28][CH2:27][CH:26]=1)#[CH:24]>C(Cl)Cl>[C:25]1([C:23]#[C:24][C:7]2[CH:8]=[CH:9][C:4]([C:1](=[O:3])[CH3:2])=[CH:5][C:6]=2[O:21][CH3:22])[CH2:30][CH2:29][CH2:28][CH2:27][CH:26]=1

참가 물질

4

반응물 2

HCID 791281-EthynylcyclohexeneHCID 29800848Toluene-4-sulfonic acid 4-acetyl-2-methoxy-phenyl ester

생성물 1

HCID 252216071-(4-Cyclohex-1-enylethynyl-3-methoxy-phenyl)ethanone

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

This product was prepared from toluene-4-sulfonic acid 4-acetyl-2-methoxy-phenyl ester and 1-ethynyl-cyclohexene following the general procedure for the Sonogashira cross-coupling process described above. Chromatography eluent: DCM; yield (114 mg, 90%); 1H NMR δ (CDCl3): 7.53-7.41 (m, 3H), 6.29 (m, 1H), 3.92 (s, 3H), 2.51 (s, 3H), 2.31-2.12 (dm, 4H), 1.73-1.57 (m, 4H); LCMS m/z: 254.

후처리

  1. customyield (114 mg, 90%)

출처 및 근거

ORD 기록
ord-dc315de689f544b883d3cae1f9f48485
출처 데이터셋
uspto-grants-2013_07
특허 번호
US08487109B2

연결된 노트

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