Sodium Hydroxide → 1-(6-Methylpyrimidin-4-yl)piperidin-4-amine

HRID 451469노트

반응식

HRID 451469 반응식
Cl.Cl.[CH3:3][C:4]1[N:9]=[CH:8][N:7]=[C:6]([N:10]2[CH2:15][CH2:14][CH:13]([NH2:16])[CH2:12][CH2:11]2)[CH:5]=1.[OH-].[Na+]>C(Cl)Cl>[CH3:3][C:4]1[N:9]=[CH:8][N:7]=[C:6]([N:10]2[CH2:15][CH2:14][CH:13]([NH2:16])[CH2:12][CH2:11]2)[CH:5]=1

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 673421331-(6-Methylpyrimidin-4-yl)piperidin-4-amine dihydrochloride

생성물 1

HCID 166433141-(6-Methylpyrimidin-4-yl)piperidin-4-amine

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

1-(6-Methylpyrimidin-4-yl)piperidin-4-amine dihydrochloride (see example 30b, 2 g, 7.54 mmol) was neutralized with 2 N NaOH solution and CH2Cl2, the aqueous layers were extracted three times with CH2Cl2, the combines organic layers were dried over Na2SO4, filtered and the solvent was evaporated. The title compound was obtained as a brown oil (1.31 g, 90%).

후처리

  1. extractionthe aqueous layers were extracted three times with CH2Cl2
  2. dry with materialthe combines organic layers were dried over Na2SO4
  3. filtrationfiltered
  4. customthe solvent was evaporated

출처 및 근거

ORD 기록
ord-d1a97e2157054c4bac830b1e9fca58d2
출처 데이터셋
uspto-grants-2013_07
특허 번호
US08486967B2

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