Hydrochloric Acid → HCID 67342484, 화합물

HRID 451486노트

반응식

HRID 451486 반응식
[CH3:1][C:2]1[CH:3]=[C:4]([C:25]2[CH:26]=[C:27]([CH:37]=[CH:38][CH:39]=2)[CH2:28][NH:29]C(=O)OC(C)(C)C)[C:5]2[N:6]([N:8]=[C:9]([NH:11][CH:12]3[CH2:17][CH2:16][N:15]([C:18]4[CH:23]=[C:22]([CH3:24])[N:21]=[CH:20][N:19]=4)[CH2:14][CH2:13]3)[N:10]=2)[CH:7]=1.[ClH:40]>C(Cl)Cl.CCOCC>[ClH:40].[ClH:40].[NH2:29][CH2:28][C:27]1[CH:26]=[C:25]([C:4]2[C:5]3[N:6]([N:8]=[C:9]([NH:11][CH:12]4[CH2:13][CH2:14][N:15]([C:18]5[CH:23]=[C:22]([CH3:24])[N:21]=[CH:20][N:19]=5)[CH2:16][CH2:17]4)[N:10]=3)[CH:7]=[C:2]([CH3:1])[CH:3]=2)[CH:39]=[CH:38][CH:37]=1

참가 물질

5

반응물 2

HCID 313Hydrochloric AcidHCID 67343427HCID 67343427, 화합물

생성물 1

HCID 67342484HCID 67342484, 화합물수율 89%

시약·촉매·용매 2

HCID 3283Diethyl Ether용매HCID 6344Dichloromethane용매

실험 절차

To a solution of tert-butyl 3-(6-methyl-2-(1-(6-methylpyrimidin-4-yl)piperidin-4-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-8-yl)benzylcarbamate (46 mg, 87.0 μmol) in methylene chloride (1 mL) was added 2 M solution of HCl in Ether (500 μL). The suspension was stirred at room temperature over night. The solvent was decanted and the residue was digerated with diethyl ether three times. The title compound was dried under reduced pressure and was obtained as a yellow solid (39 mg, 89%). MS ISP (m/e): 429.3 (100) [(M+H)+], 412.4 (57).

후처리

  1. customThe solvent was decanted
  2. dry with materialThe title compound was dried under reduced pressure

출처 및 근거

ORD 기록
ord-0738f7ef6465464898f6e2c1113b67ed
출처 데이터셋
uspto-grants-2013_07
특허 번호
US08486967B2

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