Water → 3-(2,5-dimethyl-1H-pyrrol-1-yl)-1-methyl-1H-pyrazole

HRID 45149

반응식

HRID 45149 반응식
[CH3:1][N:2]1[CH:6]=[CH:5][C:4]([NH2:7])=[N:3]1.[CH2:8]([CH2:12][C:13](=O)[CH3:14])[C:9]([CH3:11])=O.O>C1(C)C=CC=CC=1.CC(O)=O>[CH3:14][C:13]1[N:7]([C:4]2[CH:5]=[CH:6][N:2]([CH3:1])[N:3]=2)[C:9]([CH3:11])=[CH:8][CH:12]=1

참가 물질

6

반응물 3

HCID 962Water2회HCID 80352,5-HexanedioneHCID 1372541-Methyl-3-aminopyrazole

생성물 1

HCID 132489953-(2,5-dimethyl-1H-pyrrol-1-yl)-1-methyl-1H-pyrazole

시약·촉매·용매 2

HCID 176Acetic Acid용매HCID 1140Toluene용매

실험 절차

To a solution of 1-methyl-1H-pyrazol-3-amine (9.5 g, 98 mmol) and acetonylacetone (11.2 g, 98 mmol) in toluene (150 mL), AcOH (1.5 mL) is added, heated to reflux with a water separator until the formation of water ceased. Concentrated to dry. The residue is purified by flash column to give product.

후처리

  1. temperatureheated
  2. concentrationConcentrated
  3. customto dry
  4. customThe residue is purified by flash column
  5. customto give product

출처 및 근거

ORD 기록
ord-0937fb3db8924a38996162cfa19c76bf
출처 데이터셋
uspto-grants-2013_09
특허 번호
US08541432B2

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