Hydrochloric Acid → 1-(2-Chloropyridin-4-yl)piperidin-4-amine dihydrochloride
반응식
[Cl:1][C:2]1[CH:7]=[C:6]([N:8]2[CH2:13][CH2:12][CH:11]([NH:14]C(=O)OC(C)(C)C)[CH2:10][CH2:9]2)[CH:5]=[CH:4][N:3]=1.[ClH:22]>ClCCl>[ClH:1].[ClH:22].[Cl:1][C:2]1[CH:7]=[C:6]([N:8]2[CH2:13][CH2:12][CH:11]([NH2:14])[CH2:10][CH2:9]2)[CH:5]=[CH:4][N:3]=1참가 물질
4
실험 절차
To a solution of tert-butyl 1-(2-chloropyridin-4-yl)piperidin-4-ylcarbamate (1.00 g, 3.21 mmol) in dichloromethane (16 mL) was added HCl (2 M in diethylether, 8.02 mL, 16.0 mmol) and the reaction mixture was stirred at room temperature over night for 18 hours. The mixture was then filtered off and the white precipitate washed with dichloromethane and diethylether and dried to afford the title compound (913 mg, 99%) as a white solid. MS ISP (m/e): 212.1/214.1 [(M+H)+].
후처리
- filtrationThe mixture was then filtered off
- washthe white precipitate washed with dichloromethane and diethylether
- customdried
출처 및 근거
- ORD 기록
- ord-0ee34b7580454f07942e541b9b7384c2
- 출처 데이터셋
- uspto-grants-2013_07
- 특허 번호
- US08486967B2
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