Hydrazine hydrate (1:1) → 6-hydrazinyl-N,N-dimethylpyridine-3-sulfonamide

HRID 45223노트

반응식

HRID 45223 반응식
Cl[C:2]1[N:7]=[CH:6][C:5]([S:8]([N:11]([CH3:13])[CH3:12])(=[O:10])=[O:9])=[CH:4][CH:3]=1.O.[NH2:15][NH2:16]>CCO>[NH:15]([C:2]1[N:7]=[CH:6][C:5]([S:8]([N:11]([CH3:13])[CH3:12])(=[O:10])=[O:9])=[CH:4][CH:3]=1)[NH2:16]

참가 물질

4

반응물 2

HCID 24654Hydrazine hydrate (1:1)HCID 47298556-chloro-N,N-dimethylpyridine-3-sulfonamide

생성물 1

HCID 52676846-hydrazinyl-N,N-dimethylpyridine-3-sulfonamide수율 85.1%

시약·촉매·용매 1

HCID 702Ethanol용매

반응 조건

온도
80 °C

실험 절차

A mixture of 1.9 g (8.8 mmol) of 6-chloro-N,N-dimethylpyridine-3-sulfonamide and 4.6 mL (91.5 mmol) of hydrazine monohydrate in 10 mL of EtOH is heated for 2 hours at 80° C. The precipitate obtained, after cooling to room temperature, is filtered off and then washed with 10 mL of EtOH and dried under vacuum. 1.62 g of 6-hydrazino-N,N-dimethylpyridine-3-sulfonamide are obtained in the form of a white powder.

후처리

  1. customThe precipitate obtained
  2. temperatureafter cooling to room temperature
  3. filtrationis filtered off
  4. washwashed with 10 mL of EtOH
  5. customdried under vacuum

출처 및 근거

ORD 기록
ord-03e3e2556767432c8364a95b97ccb0ce
출처 데이터셋
uspto-grants-2013_09
특허 번호
US08541455B2

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