Water → HCID 66784310, 화합물

HRID 452488

반응식

HRID 452488 반응식
[Br:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([OH:8])=O)=[C:4]([CH3:11])[CH:3]=1.[F:12][C:13]([F:17])([F:16])[CH2:14][NH2:15].Cl.C(N(CC)CCCN=C=NCC)C.O>CN(C)C=O>[Br:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([NH:15][CH2:14][C:13]([F:17])([F:16])[F:12])=[O:8])=[C:4]([CH3:11])[CH:3]=1

참가 물질

6

반응물 4

HCID 962WaterHCID 9773Ethanamine, 2,2,2-trifluoro-HCID 995704-Bromo-2-methylbenzoic acidHCID 99645121-(3-Diethylaminopropyl)-3-ethylcarbodiimide hydrochloride

생성물 1

HCID 66784310HCID 66784310, 화합물수율 58.1%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

In a solution of 5.00 g of 4-bromo-2-methyl benzoic acid and 3.45 g of 2,2,2-trifluoroethylamine in 30 ml of N,N-dimethylformamide, 5.79 g of 1-[3-(diethylamino)propyl]-3-ethylcarbodiimide hydrochloride was added with stirring at room temperature, and stirred at the same temperature for 1.5 hour. After the completion of the reaction, 80 ml of water was added, and precipitated crystal was filtered off, washed with water and dried to obtain 4.00 g of the aimed product as white crystal.

후처리

  1. stirringstirred at the same temperature for 1.5 hour
  2. additionwas added
  3. customprecipitated crystal
  4. filtrationwas filtered off
  5. washwashed with water
  6. customdried

출처 및 근거

ORD 기록
ord-ce9d8834890c497b84e596722dc2eec6
출처 데이터셋
uspto-grants-2013_07
특허 번호
US08492311B2

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