Methylamine → HCID 44219587, 화합물

HRID 452559

반응식

HRID 452559 반응식
Br[CH2:2][C:3](=O)[CH:4]([C:13]1[CH:18]=[CH:17][C:16]([O:19][CH3:20])=[CH:15][CH:14]=1)[CH2:5][C:6]1[CH:11]=[CH:10][C:9]([Br:12])=[CH:8][CH:7]=1.[CH3:22][NH2:23].Br.C(S[C:28](=[NH:30])[NH2:29])C.[OH-].[Na+]>CO>[Br:12][C:9]1[CH:10]=[CH:11][C:6]([CH2:5][CH:4]([C:3]2[N:30]=[C:28]([NH2:29])[N:23]([CH3:22])[CH:2]=2)[C:13]2[CH:18]=[CH:17][C:16]([O:19][CH3:20])=[CH:15][CH:14]=2)=[CH:7][CH:8]=1

참가 물질

6

반응물 4

HCID 6329MethylamineHCID 14798Sodium HydroxideHCID 200213S-Ethylisothiuronium bromideHCID 86650847HCID 86650847, 화합물

생성물 1

HCID 44219587HCID 44219587, 화합물수율 100.7%

시약·촉매·용매 1

HCID 887Methanol용매

반응 조건

온도
25 °C

실험 절차

1-bromo-4-(4-bromophenyl)-3-(4-methoxyphenyl)butan-2-one (0.15 g, 0.36 mmol) was dissolved in methanol (1.8 mL) and methylamine (0.36 mL, 0.72 mmol, 2M solution in methanol) was added in one portion and the reaction was allowed to stir at 25° C. for 0.5 hour. S-ethylisothiourea hydrobromide (0.27 mg, 1.46 mmol) and NaOH (0.61 mL, 1.82 mmol, 3M solution in water) were added to the solution and the resulting solution was allowed to stir at 25° C. for 16 hours. The reaction was purified using reverse phase C-18 chromatography (acetontitrile and water system) to afford 140 mg of 4-[2-(4-bromophenyl)-1-(4-methoxyphenyl)ethyl]-1-methyl-1H-imidazol-2-amine as a yellow solid.

후처리

  1. stirringto stir at 25° C. for 16 hours
  2. customThe reaction was purified

출처 및 근거

ORD 기록
ord-af88c8423c9e4317bb520879787aed68
출처 데이터셋
uspto-grants-2013_07
특허 번호
US08492387B2

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