Acetic Acid → HCID 178476642, 화합물
반응식
[CH3:1][N:2]([C:4]([N:6]=[C:7]([NH2:9])[NH2:8])=[NH:5])[CH3:3].Cl.[C:11]([OH:14])(=[O:13])[CH3:12].[OH-].[Na+]>O>[CH3:1][N:2]([C:4]([NH:6][C:7]([NH2:9])=[NH:8])=[NH:5])[CH3:3].[C:11]([O-:14])(=[O:13])[CH3:12]참가 물질
5
반응 조건
- 온도
- 30 °C
실험 절차
1 Kg (1 equivalent) of metformin hydrochloride and 2 L of water, and then 0.5 L (1.45 equivalents) of acetic acid were added to a reactor, and stirred for 2 hours at 30° C. to dissolve thoroughly. Then 289.8 g (1.2 equivalents) of aqueous solution of sodium hydroxide were added to the reaction solution for 1 hour. The resulting crystal was filtered and washed with acetone, and then dried at 60° C. to obtain 601 g of metformin acetate (yield: 52.7%).
후처리
- dissolutionto dissolve thoroughly
- filtrationThe resulting crystal was filtered
- washwashed with acetone
- customdried at 60° C.
출처 및 근거
- ORD 기록
- ord-454cebb606194248a921a8f6ef541f6e
- 출처 데이터셋
- uspto-grants-2013_09
- 특허 번호
- US08541474B2
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