Acetic Acid → HCID 178476642, 화합물

HRID 45298

반응식

HRID 45298 반응식
[CH3:1][N:2]([C:4]([N:6]=[C:7]([NH2:9])[NH2:8])=[NH:5])[CH3:3].Cl.[C:11]([OH:14])(=[O:13])[CH3:12].[OH-].[Na+]>O>[CH3:1][N:2]([C:4]([NH:6][C:7]([NH2:9])=[NH:8])=[NH:5])[CH3:3].[C:11]([O-:14])(=[O:13])[CH3:12]

참가 물질

5

반응물 3

HCID 176Acetic AcidHCID 14219Metformin HydrochlorideHCID 14798Sodium Hydroxide

생성물 1

HCID 178476642HCID 178476642, 화합물수율 52.7%

시약·촉매·용매 1

HCID 962Water용매

반응 조건

온도
30 °C

실험 절차

1 Kg (1 equivalent) of metformin hydrochloride and 2 L of water, and then 0.5 L (1.45 equivalents) of acetic acid were added to a reactor, and stirred for 2 hours at 30° C. to dissolve thoroughly. Then 289.8 g (1.2 equivalents) of aqueous solution of sodium hydroxide were added to the reaction solution for 1 hour. The resulting crystal was filtered and washed with acetone, and then dried at 60° C. to obtain 601 g of metformin acetate (yield: 52.7%).

후처리

  1. dissolutionto dissolve thoroughly
  2. filtrationThe resulting crystal was filtered
  3. washwashed with acetone
  4. customdried at 60° C.

출처 및 근거

ORD 기록
ord-454cebb606194248a921a8f6ef541f6e
출처 데이터셋
uspto-grants-2013_09
특허 번호
US08541474B2

연결된 노트

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