Metformin Hydrochloride → HCID 178476642, 화합물
반응식
[CH3:1][N:2]([C:4]([N:6]=[C:7]([NH2:9])[NH2:8])=[NH:5])[CH3:3].Cl.O.O.O.[C:14]([O-:17])(=[O:16])[CH3:15].[Na+]>O>[CH3:1][N:2]([C:4]([NH:6][C:7]([NH2:9])=[NH:8])=[NH:5])[CH3:3].[C:14]([O-:17])(=[O:16])[CH3:15]참가 물질
4
실험 절차
20.0 g (1 equivalent) of metformin hydrochloride, 50 Ml of water, and 19.72 g (1.2 equivalents) of sodium acetate trihydrate were added to a reactor, and stirred. Then the resulting crystal was filtered and washed with acetone, and then dried at 60° C. to obtain 11.72 g of metformin acetate (yield: 51.3%).
후처리
- filtrationThen the resulting crystal was filtered
- washwashed with acetone
- customdried at 60° C.
출처 및 근거
- ORD 기록
- ord-8f6f02ec54e8446e91f4b5525381d122
- 출처 데이터셋
- uspto-grants-2013_09
- 특허 번호
- US08541474B2
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