Acetic Acid → HCID 178476642, 화합물
반응식
[CH3:1][N:2]([C:4]([NH:6][C:7]([NH2:9])=[NH:8])=[NH:5])[CH3:3].C(O)(C)C.[C:14]([OH:17])(=[O:16])[CH3:15]>O>[CH3:1][N:2]([C:4]([NH:6][C:7]([NH2:9])=[NH:8])=[NH:5])[CH3:3].[C:14]([O-:17])(=[O:16])[CH3:15]참가 물질
5
실험 절차
78 g (1 equivalent) of metformin free base, 234 Ml of isopropanol, 234 Ml of water and 57 Ml (1.65 equivalents) of acetic acid were added to a reactor, and stirred. The resulting crystal was filtered and washed with isopropanol, and then dried at 60° C. to obtain 54.6 g of metformin acetate (yield: 47.8%).
후처리
- filtrationThe resulting crystal was filtered
- washwashed with isopropanol
- customdried at 60° C.
출처 및 근거
- ORD 기록
- ord-cd5a98c6f5d745438361e4b8efe6e631
- 출처 데이터셋
- uspto-grants-2013_09
- 특허 번호
- US08541474B2
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