Sodium Hydroxide → 2-Amino-4-methyl-thiazole-5-carboxylic acid

HRID 45308

반응식

HRID 45308 반응식
[NH2:1][C:2]1[S:3][C:4]([C:8]([O:10]CC)=[O:9])=[C:5]([CH3:7])[N:6]=1.[OH-].[Na+]>O1CCCC1.O>[NH2:1][C:2]1[S:3][C:4]([C:8]([OH:10])=[O:9])=[C:5]([CH3:7])[N:6]=1

참가 물질

5

반응물 2

HCID 14798Sodium HydroxideHCID 343747Ethyl 2-amino-4-methylthiazole-5-carboxylate

생성물 1

HCID 8322432-Amino-4-methyl-thiazole-5-carboxylic acid수율 94%

시약·촉매·용매 2

HCID 962Water용매HCID 8028Tetrahydrofuran용매

실험 절차

A mixture of ethyl 2-amino-4-methylthiazole-5-carboxylate (6.58 g, 35.5 mmol) and NaOH (5.40 g, 135.00 mmol) in tetrahydrofuran (60 mL) and water (30 mL) was heated to reflux overnight. Tetrahydrofuran was removed by evaporation, and the residue was neutralized with 5% hydrochloric acid solution to pH 5˜6. The precipitate obtained was collected by filtration and dried to afford 2-amino-4-methylthiazole-5-carboxylic acid (5.20 g, 94%); 1H NMR (DMSO-d6, 300 MHz) δ 7.63 (s, 2H), 2.30 (s, 3H). MS (ES+) m/z 159.1 (M+1).

후처리

  1. temperaturewas heated
  2. temperatureto reflux overnight
  3. customTetrahydrofuran was removed by evaporation
  4. customThe precipitate obtained
  5. filtrationwas collected by filtration
  6. customdried

출처 및 근거

ORD 기록
ord-80b00884331e40f7ae8f1fced1fd8601
출처 데이터셋
uspto-grants-2013_09
특허 번호
US08541457B2

연결된 노트

불러오는 중…