Benzylamine → 2-Amino-4-methylthiazole-5-carboxylic Acid 4-Chlorobenzylamide

반응식

[Cl:1][C:2]1[CH:9]=[CH:8][C:5]([CH2:6][NH2:7])=[CH:4][CH:3]=1.C(N)C1C=CC=CC=1.[NH2:18][C:19]1[S:20][C:21]([C:25](O)=[O:26])=[C:22]([CH3:24])[N:23]=1>>[Cl:1][C:2]1[CH:9]=[CH:8][C:5]([CH2:6][NH:7][C:25]([C:21]2[S:20][C:19]([NH2:18])=[N:23][C:22]=2[CH3:24])=[O:26])=[CH:4][CH:3]=1

참가 물질

반응물 3

HCID 7504Benzylamine

HCID 660364-Chlorobenzylamine

HCID 8322432-Amino-4-methyl-thiazole-5-carboxylic acid

생성물 1

HCID 627933982-Amino-4-methylthiazole-5-carboxylic Acid 4-Chlorobenzylamide수율 15%

실험 절차

Following the procedure as described in Preparation 1, making variation only as required to use 4-chlorobenzylamine to replace benzylamine to react with 2-amino-4-methylthiazole-5-carboxylic acid, the title compound was obtained as a white solid in 15% yield; 1H NMR (CD3OD, 300 MHz) δ 7.26-7.32 (m, 4H), 4.41 (s, 2H), 2.38 (s, 3H). MS (ES+) m/z 282.1 (M+1).